Assay Detail
Binding
CHEMBL3226835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JNK2 (unknown origin) using biotinylated ATF2 by HTRF method
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.09 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3220502 | — | — | 1 | 9.62 |
| CHEMBL3220499 | — | — | 1 | 9.29 |
| CHEMBL3220496 | — | — | 1 | 9.22 |
| CHEMBL3220497 | — | — | 1 | 9.17 |
| CHEMBL3220498 | — | — | 1 | 9.16 |
| CHEMBL3220500 | — | — | 1 | 9.15 |
| CHEMBL3220494 | — | — | 1 | 9.00 |
| CHEMBL3220493 | — | — | 1 | 9.00 |
| CHEMBL3217784 | — | — | 1 | 8.60 |
| CHEMBL3220495 | — | — | 1 | 8.52 |
| CHEMBL3220501 | — | — | 1 | 7.47 |
| CHEMBL458997 | — | — | 1 | 7.38 |
| CHEMBL3220466 | — | — | 1 | 7.30 |
| CHEMBL3220467 | — | — | 1 | 7.09 |
| CHEMBL3220469 | — | — | 1 | 7.05 |
| CHEMBL3040440 | VS-4718 | 1.0 | 1 | 6.92 |
| CHEMBL3220479 | — | — | 1 | 6.48 |
| CHEMBL3220465 | — | — | 1 | 6.23 |
| CHEMBL3220471 | — | — | 1 | 6.22 |
| CHEMBL3220486 | — | — | 1 | 6.22 |
| CHEMBL3220474 | — | — | 1 | 6.09 |
| CHEMBL3220489 | — | — | 1 | 6.09 |
| CHEMBL3220492 | — | — | 1 | 6.07 |
| CHEMBL3220477 | — | — | 1 | 6.07 |
| CHEMBL3220487 | — | — | 1 | 5.98 |
| CHEMBL3220472 | — | — | 1 | 5.98 |
| CHEMBL3220485 | — | — | 1 | 5.85 |
| CHEMBL3220470 | — | — | 1 | 5.85 |
| CHEMBL3220475 | — | — | 1 | 5.84 |
| CHEMBL3220490 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3220502 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL3220499 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL3220496 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3220497 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL3220498 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL3220500 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL3220494 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3220493 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3217784 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3220495 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3220501 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL458997 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3220466 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3220467 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3220469 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3040440 | VS-4718 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3220479 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL3220465 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3220471 | — | IC50 | = | 603.0 | nM | 6.22 |
| CHEMBL3220486 | — | IC50 | = | 603.0 | nM | 6.22 |
| CHEMBL3220489 | — | IC50 | = | 806.0 | nM | 6.09 |
| CHEMBL3220474 | — | IC50 | = | 806.0 | nM | 6.09 |
| CHEMBL3220492 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3220477 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3220487 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL3220472 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL3220485 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL3220470 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL3220475 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL3220490 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL3220473 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL3220488 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL3220491 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL3220476 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL3220478 | — | IC50 | - | — | - | |
| CHEMBL3220504 | — | IC50 | - | — | - | |
| CHEMBL3220503 | — | IC50 | - | — | - | |
| CHEMBL3220480 | — | IC50 | - | — | - | |
| CHEMBL3220481 | — | IC50 | - | — | - | |
| CHEMBL3220468 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3220482 | — | IC50 | - | — | - | |
| CHEMBL3220483 | — | IC50 | - | — | - | |
| CHEMBL3220484 | — | IC50 | - | — | - |