Assay Detail
Binding
CHEMBL3226837
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Inhibition of JNK in rat INS cells assessed as inhibition of c-jun phosphorylation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.42 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3220495 | — | — | 1 | 8.52 |
| CHEMBL458997 | — | — | 1 | 6.31 |
| CHEMBL3040440 | VS-4718 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3220495 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL458997 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL3040440 | VS-4718 | IC50 | > | 3000.0 | nM | - |