Assay Detail
Binding
CHEMBL3226845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JNK in human U87MG cells overexpressing EGFR V3 mutant assessed as inhibition of c-jun phosphorylation after 6 hrs by ELISA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.52 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3220497 | — | — | 1 | 7.64 |
| CHEMBL458997 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3220497 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL458997 | — | EC50 | = | 41.0 | nM | 7.39 |