Assay Detail
Functional
CHEMBL3227322
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Cytotoxicity against human SiHa cells after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SiHa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Benzisothiazolones arrest the cell cycle at the G2/M phase and induce apoptosis in HeLa cells
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.47 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99313 | — | — | 1 | 4.60 |
| CHEMBL3219174 | — | — | 1 | 4.53 |
| CHEMBL3219172 | — | — | 1 | 4.49 |
| CHEMBL3219173 | — | — | 1 | 4.45 |
| CHEMBL3219171 | — | — | 1 | 4.42 |
| CHEMBL3219170 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99313 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL3219174 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL3219172 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL3219173 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL3219171 | — | IC50 | = | 38100.0 | nM | 4.42 |
| CHEMBL3219170 | — | IC50 | = | 48300.0 | nM | 4.32 |