Assay Detail
Binding
CHEMBL3227883
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Inhibition of human recombinant HDAC1 after 1 hr by luminescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.23 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3126833 | — | — | 1 | 9.70 |
| CHEMBL1836142 | THAILANDEPSIN A | — | 1 | 9.55 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 9.51 |
| CHEMBL3218562 | — | — | 1 | 9.32 |
| CHEMBL3218563 | — | — | 1 | 9.03 |
| CHEMBL1836145 | THAILANDEPSIN B | — | 1 | 8.92 |
| CHEMBL3218564 | — | — | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3126833 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1836142 | THAILANDEPSIN A | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL3218562 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL3218563 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL1836145 | THAILANDEPSIN B | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3218564 | — | IC50 | = | 2.6 | nM | 8.59 |