Assay Detail
Binding
CHEMBL3231164
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Displacement of 17beta-[3H]estradiol from rabbit uterine estrogen receptor after 16 to 18 hrs by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and estrogenic properties of 17-epi-ethynylestradiol and its ether derivatives epimestranol and epiquinestrol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.34 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL691 | ETHINYL ESTRADIOL | 4.0 | 1 | 9.62 |
| CHEMBL1628202 | — | — | 1 | 7.82 |
| CHEMBL1201151 | MESTRANOL | 4.0 | 1 | 6.70 |
| CHEMBL1201165 | QUINESTROL | 4.0 | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL691 | ETHINYL ESTRADIOL | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL1628202 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1201151 | MESTRANOL | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1201165 | QUINESTROL | IC50 | = | 6000.0 | nM | 5.22 |