Assay Detail
Binding
CHEMBL3231509
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Competitive antagonist at alpha-adrenergic receptor in New Zealand rabbit aorta assessed as methoxamine-induced contraction after 45 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Absolute configuration of glycerol derivatives. 7. Enantiomers of 2-[[[2-(2,6-dimethoxyphenoxy)ethyl]amino]methyl]-1,4-benzodioxane (WB-4101), a potent competitive alpha-adrenergic antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.40 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215421 | — | — | 1 | 9.02 |
| CHEMBL25554 | — | — | 1 | 8.83 |
| CHEMBL214986 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215421 | — | Kd | = | 0.955 | nM | 9.02 |
| CHEMBL25554 | — | Kd | = | 1.479 | nM | 8.83 |
| CHEMBL214986 | — | Kd | = | 44.67 | nM | 7.35 |