Assay Detail
Binding
CHEMBL3238609
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HDAC6 using fluorogenic tetrapeptide RHKKAc as substrate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.74 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 9.38 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.54 |
| CHEMBL561209 | — | — | 1 | 7.43 |
| CHEMBL556332 | — | — | 1 | 7.38 |
| CHEMBL3235790 | — | — | 1 | 6.39 |
| CHEMBL3235463 | — | — | 1 | 5.55 |
| CHEMBL538364 | — | — | 1 | 5.49 |
| CHEMBL3235787 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 0.419 | nM | 9.38 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 28.6 | nM | 7.54 |
| CHEMBL561209 | — | IC50 | = | 36.8 | nM | 7.43 |
| CHEMBL556332 | — | IC50 | = | 41.8 | nM | 7.38 |
| CHEMBL3235790 | — | IC50 | = | 408.0 | nM | 6.39 |
| CHEMBL3235463 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL538364 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL3235787 | — | IC50 | = | 16700.0 | nM | 4.78 |