Assay Detail
Binding
CHEMBL3238721
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Inhibition of DPP4 (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.79 | 8.46 |
| Ki | 1 | 6.90 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 8.46 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.72 |
| CHEMBL77538 | — | — | 1 | 7.66 |
| CHEMBL385517 | SAXAGLIPTIN ANHYDROUS | 4.0 | 1 | 7.30 |
| CHEMBL98408 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL77538 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL385517 | SAXAGLIPTIN ANHYDROUS | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL98408 | — | Ki | = | 126.0 | nM | 6.90 |