Assay Detail
Binding
CHEMBL3239091
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Inhibition of human DGAT1
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.77 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233885 | — | — | 1 | 7.96 |
| CHEMBL3233889 | — | — | 1 | 7.92 |
| CHEMBL3233888 | — | — | 1 | 7.55 |
| CHEMBL2036730 | — | — | 1 | 7.44 |
| CHEMBL3233871 | — | — | 1 | 7.44 |
| CHEMBL3233872 | — | — | 1 | 7.43 |
| CHEMBL3233886 | — | — | 1 | 7.39 |
| CHEMBL3233883 | — | — | 1 | 7.25 |
| CHEMBL3233887 | — | — | 1 | 7.24 |
| CHEMBL3233884 | — | — | 1 | 7.19 |
| CHEMBL3233891 | — | — | 1 | 6.91 |
| CHEMBL3233879 | — | — | 1 | 6.80 |
| CHEMBL3233878 | — | — | 1 | 6.75 |
| CHEMBL3233890 | — | — | 1 | 6.56 |
| CHEMBL3233877 | — | — | 1 | 6.35 |
| CHEMBL3233875 | — | — | 1 | 5.69 |
| CHEMBL3233873 | — | — | 1 | 5.62 |
| CHEMBL3233876 | — | — | 1 | 5.56 |
| CHEMBL3233874 | — | — | 1 | 5.26 |
| CHEMBL3233881 | — | — | 1 | 5.14 |
| CHEMBL3233882 | — | — | 1 | - |
| CHEMBL3233880 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233885 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3233889 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3233888 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2036730 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3233871 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3233872 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3233886 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3233883 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3233887 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3233884 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3233891 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL3233879 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3233878 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3233890 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL3233877 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL3233875 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL3233873 | — | IC50 | = | 2393.0 | nM | 5.62 |
| CHEMBL3233876 | — | IC50 | = | 2735.0 | nM | 5.56 |
| CHEMBL3233874 | — | IC50 | = | 5548.0 | nM | 5.26 |
| CHEMBL3233881 | — | IC50 | = | 7257.0 | nM | 5.14 |
| CHEMBL3233882 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3233880 | — | IC50 | > | 10000.0 | nM | - |