Assay Detail
Binding
CHEMBL3239336
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Inhibition of Escherichia coli DNA polymerase 3 beta assessed as inhibition of 5-carboxyfluorescein-QLDLF binding by fluorescence polarization-based competition assay
11
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 3.43 | 3.94 |
| Ki | 5 | 3.68 | 4.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233038 | — | — | 2 | 4.19 |
| CHEMBL3235575 | — | — | 2 | 3.70 |
| CHEMBL1466999 | — | — | 2 | 3.67 |
| CHEMBL106708 | — | — | 2 | 3.55 |
| CHEMBL3235577 | — | — | 2 | 3.30 |
| CHEMBL3235576 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233038 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL3233038 | — | IC50 | = | 115000.0 | nM | 3.94 |
| CHEMBL3235575 | — | Ki | = | 199000.0 | nM | 3.70 |
| CHEMBL1466999 | — | Ki | = | 216000.0 | nM | 3.67 |
| CHEMBL106708 | — | Ki | = | 280000.0 | nM | 3.55 |
| CHEMBL3235575 | — | IC50 | = | 358000.0 | nM | 3.45 |
| CHEMBL1466999 | — | IC50 | = | 389000.0 | nM | 3.41 |
| CHEMBL3235577 | — | Ki | = | 499000.0 | nM | 3.30 |
| CHEMBL106708 | — | IC50 | = | 504000.0 | nM | 3.30 |
| CHEMBL3235577 | — | IC50 | = | 899000.0 | nM | 3.05 |
| CHEMBL3235576 | — | IC50 | > | 1000000.0 | nM | - |