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Assay Detail

CHEMBL3239379

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of AIP-1-induced AgrC-I activation in Staphylococcus aureus RN6390B after 55 mins by beta-lactamase reporter assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Staphylococcus aureus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors.
Murray EJ, Crowley RC, Truman A, Clarke SR, Cottam JA, Jadhav GP, Steele VR, O'Shea P, Lindholm C, Cockayne A, Chhabra SR, Chan WC, Williams P.
J Med Chem (2014) 57 : 2813 -2819
PubMed 24592914 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.71 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3235590 1 5.52
CHEMBL3235589 1 5.22
CHEMBL3235595 1 5.00
CHEMBL3235591 1 4.89
CHEMBL3235596 1 4.89
CHEMBL3235597 1 4.85
CHEMBL1213027 1 4.70
CHEMBL3235588 1 4.68
CHEMBL8483 1 4.66
CHEMBL3235581 1 4.66
CHEMBL1213025 1 4.55
CHEMBL1213028 1 4.52
CHEMBL208383 1 4.43
CHEMBL1213657 1 4.38
CHEMBL3235594 1 4.38
CHEMBL3235582 1 4.06
CHEMBL3235600 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3235590 IC50 = 3000.0 nM 5.52
CHEMBL3235589 IC50 = 6000.0 nM 5.22
CHEMBL3235595 IC50 = 10000.0 nM 5.00
CHEMBL3235591 IC50 = 13000.0 nM 4.89
CHEMBL3235596 IC50 = 13000.0 nM 4.89
CHEMBL3235597 IC50 = 14000.0 nM 4.85
CHEMBL1213027 IC50 = 20000.0 nM 4.70
CHEMBL3235588 IC50 = 21000.0 nM 4.68
CHEMBL8483 IC50 = 22000.0 nM 4.66
CHEMBL3235581 IC50 = 22000.0 nM 4.66
CHEMBL1213025 IC50 = 28000.0 nM 4.55
CHEMBL1213028 IC50 = 30000.0 nM 4.52
CHEMBL208383 IC50 = 37000.0 nM 4.43
CHEMBL1213657 IC50 = 42000.0 nM 4.38
CHEMBL3235594 IC50 = 42000.0 nM 4.38
CHEMBL3235582 IC50 = 88000.0 nM 4.06
CHEMBL3235600 IC50 - -