Assay Detail
Binding
CHEMBL3239778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method
23
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.91 | 7.52 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.52 |
| CHEMBL3237541 | — | — | 1 | 6.11 |
| CHEMBL3237537 | — | — | 1 | 5.46 |
| CHEMBL3237533 | — | — | 1 | 4.91 |
| CHEMBL3237782 | — | — | 1 | 4.87 |
| CHEMBL571510 | — | — | 1 | 4.87 |
| CHEMBL278020 | NEOSTIGMINE | 4.0 | 1 | 4.85 |
| CHEMBL3237539 | — | — | 1 | 4.81 |
| CHEMBL3237781 | — | — | 1 | 4.79 |
| CHEMBL3237779 | — | — | 1 | 4.73 |
| CHEMBL3237531 | — | — | 1 | 4.67 |
| CHEMBL3237778 | — | — | 1 | 4.64 |
| CHEMBL3237777 | — | — | 1 | 4.62 |
| CHEMBL3237783 | — | — | 1 | 4.55 |
| CHEMBL3237532 | — | — | 1 | 4.52 |
| CHEMBL3237542 | — | — | 1 | 4.43 |
| CHEMBL3237540 | — | — | 1 | 4.38 |
| CHEMBL3237535 | — | — | 1 | 4.29 |
| CHEMBL3237538 | — | — | 1 | 4.27 |
| CHEMBL3237780 | — | — | 1 | - |
| CHEMBL3237536 | — | — | 1 | - |
| CHEMBL3237784 | — | — | 1 | - |
| CHEMBL3237534 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3237541 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3237537 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL3237533 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL3237782 | — | IC50 | = | 13660.0 | nM | 4.87 |
| CHEMBL571510 | — | IC50 | = | 13460.0 | nM | 4.87 |
| CHEMBL278020 | NEOSTIGMINE | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL3237539 | — | IC50 | = | 15640.0 | nM | 4.81 |
| CHEMBL3237781 | — | IC50 | = | 16110.0 | nM | 4.79 |
| CHEMBL3237779 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL3237531 | — | IC50 | = | 21260.0 | nM | 4.67 |
| CHEMBL3237778 | — | IC50 | = | 22740.0 | nM | 4.64 |
| CHEMBL3237777 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL3237783 | — | IC50 | = | 28030.0 | nM | 4.55 |
| CHEMBL3237532 | — | IC50 | = | 30190.0 | nM | 4.52 |
| CHEMBL3237542 | — | IC50 | = | 36840.0 | nM | 4.43 |
| CHEMBL3237540 | — | IC50 | = | 41480.0 | nM | 4.38 |
| CHEMBL3237535 | — | IC50 | = | 51180.0 | nM | 4.29 |
| CHEMBL3237538 | — | IC50 | = | 54050.0 | nM | 4.27 |
| CHEMBL3237780 | — | Inhibition | = | 46.09 | % | - |
| CHEMBL3237536 | — | Inhibition | = | 47.2 | % | - |
| CHEMBL3237784 | — | Inhibition | = | 45.99 | % | - |
| CHEMBL3237534 | — | Inhibition | = | 34.63 | % | - |