Assay Detail
Binding
CHEMBL3239797
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRAF (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent progress in the identification of BRAF inhibitors as anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.94 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526479 | — | — | 1 | 10.52 |
| CHEMBL497671 | — | — | 1 | 9.66 |
| CHEMBL498674 | — | — | 1 | 9.47 |
| CHEMBL3133758 | — | — | 1 | 7.66 |
| CHEMBL2348989 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526479 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL497671 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL498674 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL3133758 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2348989 | — | IC50 | = | 43.0 | nM | 7.37 |