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Assay Detail

CHEMBL3239995

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human MCF10 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type MCF10
Confidence 1 — Organism
Curated By Autocuration

Target

MCF10 (CHEMBL613878)
Type CELL-LINE
Organism Homo sapiens

Publication

Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata.
G-Dayanandan N, Paulsen JL, Viswanathan K, Keshipeddy S, Lombardo MN, Zhou W, Lamb KM, Sochia AE, Alverson JB, Priestley ND, Wright DL, Anderson AC.
J Med Chem (2014) 57 : 2643 -2656
PubMed 24568657 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.15 4.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3234120 1 4.30
CHEMBL3234320 1 4.22
CHEMBL1270734 1 4.20
CHEMBL1270837 1 4.13
CHEMBL457905 1 4.10
CHEMBL3234323 1 4.10
CHEMBL3234318 1 4.02
CHEMBL3234116 1 -
CHEMBL3234117 1 -
CHEMBL3234118 1 -
CHEMBL3234119 1 -
CHEMBL3234317 1 -
CHEMBL3234319 1 -
CHEMBL3234321 1 -
CHEMBL3234322 1 -
CHEMBL3234324 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3234120 IC50 = 50000.0 nM 4.30
CHEMBL3234320 IC50 = 60000.0 nM 4.22
CHEMBL1270734 IC50 = 63000.0 nM 4.20
CHEMBL1270837 IC50 = 74000.0 nM 4.13
CHEMBL457905 IC50 = 80000.0 nM 4.10
CHEMBL3234323 IC50 = 80000.0 nM 4.10
CHEMBL3234318 IC50 = 96000.0 nM 4.02
CHEMBL3234116 IC50 - -
CHEMBL3234117 IC50 = 216000.0 nM -
CHEMBL3234118 IC50 = 148000.0 nM -
CHEMBL3234119 IC50 - -
CHEMBL3234317 IC50 - -
CHEMBL3234319 IC50 - -
CHEMBL3234321 IC50 = 505000.0 nM -
CHEMBL3234322 IC50 = 148000.0 nM -
CHEMBL3234324 IC50 = 216000.0 nM -