Assay Detail
Binding
CHEMBL3240047
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Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.51 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.21 |
| CHEMBL2440438 | — | — | 1 | 7.11 |
| CHEMBL450938 | (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 7.06 |
| CHEMBL2440440 | — | — | 1 | 7.05 |
| CHEMBL2440435 | — | — | 1 | 7.04 |
| CHEMBL2440441 | — | — | 1 | 6.62 |
| CHEMBL2440581 | — | — | 1 | 6.57 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 6.50 |
| CHEMBL2440439 | (P-TOLYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 6.46 |
| CHEMBL2440578 | — | — | 1 | 6.38 |
| CHEMBL2440580 | (PHENYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 6.36 |
| CHEMBL2440429 | — | — | 1 | 5.16 |
| CHEMBL2440436 | — | — | 1 | 5.06 |
| CHEMBL370662 | — | — | 1 | - |
| CHEMBL2440433 | 3,4-DICHLOROPHENYLAMINOMETHYLENEBISPHOSPHONIC ACID | — | 1 | - |
| CHEMBL191613 | 2,4-DICHLOROPHENYLAMINOMETHYLENEBISPHOSPHONIC ACID | — | 1 | - |
| CHEMBL2440434 | — | — | 1 | - |
| CHEMBL293479 | — | — | 1 | - |
| CHEMBL55371 | — | — | 1 | - |
| CHEMBL2440430 | — | — | 1 | - |
| CHEMBL2440431 | — | — | 1 | - |
| CHEMBL2440432 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2440438 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL450938 | (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL2440440 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL2440435 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL2440441 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL2440581 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL2440439 | (P-TOLYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2440578 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL2440580 | (PHENYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL2440429 | — | IC50 | = | 6917.0 | nM | 5.16 |
| CHEMBL2440436 | — | IC50 | = | 8687.0 | nM | 5.06 |
| CHEMBL370662 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2440433 | 3,4-DICHLOROPHENYLAMINOMETHYLENEBISPHOSPHONIC ACID | IC50 | > | 10000.0 | nM | - |
| CHEMBL191613 | 2,4-DICHLOROPHENYLAMINOMETHYLENEBISPHOSPHONIC ACID | IC50 | > | 10000.0 | nM | - |
| CHEMBL2440434 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL293479 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL55371 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2440430 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2440431 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2440432 | — | IC50 | > | 10000.0 | nM | - |