Assay Detail
Functional
CHEMBL3240059
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR-3 assessed as growth inhibition
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The chemistry and biology of febrifugine and halofuginone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.93 | 10.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479432 | FEBRIFUGINE | — | 2 | 10.12 |
| CHEMBL110619 | — | — | 1 | 8.80 |
| CHEMBL137542 | — | — | 1 | 8.66 |
| CHEMBL107040 | — | — | 1 | 8.55 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.75 |
| CHEMBL423905 | — | — | 1 | 7.66 |
| CHEMBL136204 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479432 | FEBRIFUGINE | EC50 | = | 0.076 | nM | 10.12 |
| CHEMBL110619 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL137542 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL107040 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL423905 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL479432 | FEBRIFUGINE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL136204 | — | EC50 | = | 6600.0 | nM | 5.18 |