Assay Detail
Binding
CHEMBL3240142
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Inhibition of truncated ROCK-2 (unknown origin) after 60 mins by IMAP assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vivo optimization of 2,3-diaminopyrazine Rho Kinase inhibitors for the treatment of glaucoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.29 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3238167 | — | — | 1 | 7.62 |
| CHEMBL3238168 | — | — | 1 | 7.44 |
| CHEMBL599163 | — | — | 1 | 7.41 |
| CHEMBL571948 | Y-39983 | 1.0 | 1 | 7.24 |
| CHEMBL3238166 | — | — | 1 | 7.19 |
| CHEMBL3238164 | — | — | 1 | 7.17 |
| CHEMBL3238163 | — | — | 1 | 7.12 |
| CHEMBL3238165 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3238167 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3238168 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL599163 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL571948 | Y-39983 | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3238166 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3238164 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3238163 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3238165 | — | IC50 | = | 75.0 | nM | 7.12 |