Assay Detail
Binding
CHEMBL3240193
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Inhibition of human recombinant COX-2 by enzyme immunoassay
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.56 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.16 |
| CHEMBL3238416 | — | — | 1 | 6.96 |
| CHEMBL241970 | — | — | 1 | 6.89 |
| CHEMBL29920 | — | — | 1 | 6.80 |
| CHEMBL3238415 | — | — | 1 | 6.52 |
| CHEMBL122 | ROFECOXIB | 4.0 | 2 | 6.44 |
| CHEMBL3238414 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3238416 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL241970 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL29920 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3238415 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3238414 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL122 | ROFECOXIB | IC50 | > | 500000.0 | nM | - |