Assay Detail
Binding
CHEMBL3240201
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Inhibition of full-length B-Raf V600E mutant (unknown origin)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.19 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3236470 | — | — | 1 | 9.70 |
| CHEMBL3236463 | — | — | 1 | 9.70 |
| CHEMBL3236471 | — | — | 1 | 9.70 |
| CHEMBL3236472 | — | — | 1 | 9.52 |
| CHEMBL3236464 | — | — | 1 | 9.52 |
| CHEMBL2144069 | — | — | 1 | 9.22 |
| CHEMBL3236198 | — | — | 1 | 8.70 |
| CHEMBL3236459 | — | — | 1 | 8.70 |
| CHEMBL3233047 | — | — | 1 | 8.52 |
| CHEMBL3236193 | — | — | 1 | 8.40 |
| CHEMBL3236467 | — | — | 1 | 8.10 |
| CHEMBL3236196 | — | — | 1 | 7.96 |
| CHEMBL3236466 | — | — | 1 | 7.96 |
| CHEMBL3236462 | — | — | 1 | 7.92 |
| CHEMBL3236195 | — | — | 1 | 7.80 |
| CHEMBL3236460 | — | — | 1 | 7.77 |
| CHEMBL3236461 | — | — | 1 | 7.72 |
| CHEMBL3236194 | — | — | 1 | 7.60 |
| CHEMBL3236468 | — | — | 1 | 7.58 |
| CHEMBL3236469 | — | — | 1 | 7.52 |
| CHEMBL3236192 | — | — | 1 | 7.48 |
| CHEMBL3236197 | — | — | 1 | 7.00 |
| CHEMBL3236191 | — | — | 1 | 6.50 |
| CHEMBL3236465 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3236470 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3236463 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3236471 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3236472 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3236464 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2144069 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3236198 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3236459 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3233047 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3236193 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3236467 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3236196 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3236466 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3236462 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3236195 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3236460 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3236461 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3236194 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3236468 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3236469 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3236192 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3236197 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3236191 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL3236465 | — | IC50 | = | 851.0 | nM | 6.07 |