Assay Detail
Binding
CHEMBL3240405
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Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate after 30 mins by spectrophotometry
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of bisindole as potent β-glucuronidase inhibitors: synthesis and in silico based studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.06 | 5.79 |
| Inhibition | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237329 | — | — | 1 | 5.79 |
| CHEMBL2430239 | — | — | 1 | 5.73 |
| CHEMBL3237336 | — | — | 1 | 5.55 |
| CHEMBL3237335 | — | — | 1 | 5.51 |
| CHEMBL3237340 | — | — | 1 | 5.37 |
| CHEMBL3237330 | — | — | 1 | 4.74 |
| CHEMBL3237343 | — | — | 1 | 4.70 |
| CHEMBL3237332 | — | — | 1 | 4.68 |
| CHEMBL3237334 | — | — | 1 | 4.67 |
| CHEMBL3237331 | — | — | 1 | 4.65 |
| CHEMBL1808316 | D-SACCHARIC ACID 1,4-LACTONE | — | 1 | 4.32 |
| CHEMBL2430214 | — | — | 1 | - |
| CHEMBL3237333 | — | — | 1 | - |
| CHEMBL3237337 | — | — | 1 | - |
| CHEMBL3237338 | — | — | 1 | - |
| CHEMBL3237339 | — | — | 1 | - |
| CHEMBL3237341 | — | — | 1 | - |
| CHEMBL3237342 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237329 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL2430239 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL3237336 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3237335 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3237340 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3237330 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL3237343 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL3237332 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL3237334 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL3237331 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL1808316 | D-SACCHARIC ACID 1,4-LACTONE | IC50 | = | 48400.0 | nM | 4.32 |
| CHEMBL2430214 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL3237333 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL3237337 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL3237338 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL3237339 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL3237341 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL3237342 | — | Inhibition | < | 50.0 | % | - |