Assay Detail
Binding
CHEMBL3240451
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-LSD from human recombinant 5-HT6 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT(7) receptor ligands among phenylpiperazine hydantoin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.47 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.15 |
| CHEMBL3233677 | — | — | 1 | 6.50 |
| CHEMBL3233676 | — | — | 1 | 6.40 |
| CHEMBL3233675 | — | — | 1 | 5.75 |
| CHEMBL3233672 | — | — | 1 | 5.71 |
| CHEMBL3233671 | — | — | 1 | 5.60 |
| CHEMBL3233678 | — | — | 1 | 5.54 |
| CHEMBL3233670 | — | — | 1 | 5.53 |
| CHEMBL3233402 | — | — | 1 | 5.51 |
| CHEMBL2079256 | — | — | 1 | 5.45 |
| CHEMBL3233401 | — | — | 1 | 5.38 |
| CHEMBL3233668 | — | — | 1 | 5.36 |
| CHEMBL3233673 | — | — | 1 | 5.13 |
| CHEMBL3233674 | — | — | 1 | 5.09 |
| CHEMBL3233669 | — | — | 1 | 5.07 |
| CHEMBL3233665 | — | — | 1 | 5.02 |
| CHEMBL3233679 | — | — | 1 | 4.97 |
| CHEMBL3233667 | — | — | 1 | 4.83 |
| CHEMBL1916746 | — | — | 1 | 4.69 |
| CHEMBL3233666 | — | — | 1 | 4.59 |
| CHEMBL1916745 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL3233677 | — | Ki | = | 314.0 | nM | 6.50 |
| CHEMBL3233676 | — | Ki | = | 395.0 | nM | 6.40 |
| CHEMBL3233675 | — | Ki | = | 1762.0 | nM | 5.75 |
| CHEMBL3233672 | — | Ki | = | 1945.0 | nM | 5.71 |
| CHEMBL3233671 | — | Ki | = | 2506.0 | nM | 5.60 |
| CHEMBL3233678 | — | Ki | = | 2879.0 | nM | 5.54 |
| CHEMBL3233670 | — | Ki | = | 2926.0 | nM | 5.53 |
| CHEMBL3233402 | — | Ki | = | 3071.0 | nM | 5.51 |
| CHEMBL2079256 | — | Ki | = | 3567.0 | nM | 5.45 |
| CHEMBL3233401 | — | Ki | = | 4139.0 | nM | 5.38 |
| CHEMBL3233668 | — | Ki | = | 4368.0 | nM | 5.36 |
| CHEMBL3233673 | — | Ki | = | 7469.0 | nM | 5.13 |
| CHEMBL3233674 | — | Ki | = | 8104.0 | nM | 5.09 |
| CHEMBL3233669 | — | Ki | = | 8611.0 | nM | 5.07 |
| CHEMBL3233665 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL3233679 | — | Ki | = | 10790.0 | nM | 4.97 |
| CHEMBL3233667 | — | Ki | = | 14650.0 | nM | 4.83 |
| CHEMBL1916746 | — | Ki | = | 20410.0 | nM | 4.69 |
| CHEMBL3233666 | — | Ki | = | 25520.0 | nM | 4.59 |
| CHEMBL1916745 | — | Ki | = | 29070.0 | nM | 4.54 |