Assay Detail
Binding
CHEMBL3240534
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Binding affinity to human ERG
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.96 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237443 | — | — | 1 | 6.14 |
| CHEMBL3237713 | — | — | 1 | 6.04 |
| CHEMBL3237444 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237443 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3237713 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3237444 | — | IC50 | = | 2000.0 | nM | 5.70 |