Assay Detail
Binding
CHEMBL3240654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT(7) receptor ligands among phenylpiperazine hydantoin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.14 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233679 | — | — | 1 | 8.52 |
| CHEMBL2079256 | — | — | 1 | 7.80 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.60 |
| CHEMBL3233676 | — | — | 1 | 7.51 |
| CHEMBL3233667 | — | — | 1 | 7.47 |
| CHEMBL3233672 | — | — | 1 | 7.35 |
| CHEMBL3233675 | — | — | 1 | 7.34 |
| CHEMBL3233668 | — | — | 1 | 7.16 |
| CHEMBL3233669 | — | — | 1 | 7.14 |
| CHEMBL3233677 | — | — | 1 | 7.11 |
| CHEMBL3233402 | — | — | 1 | 7.11 |
| CHEMBL3233401 | — | — | 1 | 7.02 |
| CHEMBL3233670 | — | — | 1 | 6.91 |
| CHEMBL3233674 | — | — | 1 | 6.91 |
| CHEMBL3233671 | — | — | 1 | 6.87 |
| CHEMBL3233666 | — | — | 1 | 6.80 |
| CHEMBL3233673 | — | — | 1 | 6.76 |
| CHEMBL1916745 | — | — | 1 | 6.68 |
| CHEMBL1916746 | — | — | 1 | 6.45 |
| CHEMBL3233678 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233679 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL2079256 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL42 | CLOZAPINE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3233676 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3233667 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL3233672 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL3233675 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL3233668 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL3233669 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL3233677 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL3233402 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL3233401 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL3233670 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL3233674 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL3233671 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL3233666 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL3233673 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL1916745 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL1916746 | — | Ki | = | 353.0 | nM | 6.45 |
| CHEMBL3233678 | — | Ki | = | 456.0 | nM | 6.34 |