Assay Detail
Binding
CHEMBL3240662
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 mins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT(7) receptor ligands among phenylpiperazine hydantoin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 8.33 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233666 | — | — | 1 | 8.52 |
| CHEMBL3233665 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233666 | — | Kd | = | 3.013 | nM | 8.52 |
| CHEMBL3233665 | — | Kd | = | 7.311 | nM | 8.14 |