Assay Detail
Binding
CHEMBL3240889
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Non-competitive inhibition of cathepsin H in goat liver using Leu-betaNA as substrate by colorimetric analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Capra hircus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 4.54 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3238003 | — | — | 1 | 5.48 |
| CHEMBL124267 | — | — | 1 | 5.09 |
| CHEMBL3237998 | — | — | 1 | 5.07 |
| CHEMBL3237996 | — | — | 1 | 4.63 |
| CHEMBL3237997 | — | — | 1 | 4.44 |
| CHEMBL3238000 | — | — | 1 | 4.41 |
| CHEMBL3237995 | — | — | 1 | 4.37 |
| CHEMBL3237999 | — | — | 1 | 4.27 |
| CHEMBL3238002 | — | — | 1 | 4.11 |
| CHEMBL1531266 | — | — | 1 | 4.04 |
| CHEMBL3238001 | — | — | 1 | 4.04 |
| CHEMBL1588015 | — | — | 1 | - |
| CHEMBL339003 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3238003 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL124267 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL3237998 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL3237996 | — | Ki | = | 23200.0 | nM | 4.63 |
| CHEMBL3237997 | — | Ki | = | 36400.0 | nM | 4.44 |
| CHEMBL3238000 | — | Ki | = | 38700.0 | nM | 4.41 |
| CHEMBL3237995 | — | Ki | = | 42500.0 | nM | 4.37 |
| CHEMBL3237999 | — | Ki | = | 53200.0 | nM | 4.27 |
| CHEMBL3238002 | — | Ki | = | 78100.0 | nM | 4.11 |
| CHEMBL1531266 | — | Ki | = | 90100.0 | nM | 4.04 |
| CHEMBL3238001 | — | Ki | = | 90100.0 | nM | 4.04 |
| CHEMBL1588015 | — | Ki | = | 588000.0 | nM | - |
| CHEMBL339003 | — | Ki | = | 112300.0 | nM | - |