Assay Detail
Binding
CHEMBL3240943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 integrase 3'-processing activity by gel-based assays
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.80 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3238134 | — | — | 1 | 5.34 |
| CHEMBL3238133 | — | — | 1 | 5.29 |
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 5.09 |
| CHEMBL3238130 | — | — | 1 | 5.07 |
| CHEMBL3238128 | — | — | 1 | 5.07 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 4.89 |
| CHEMBL3238132 | — | — | 1 | 4.89 |
| CHEMBL3238123 | — | — | 1 | 4.77 |
| CHEMBL3238129 | — | — | 1 | 4.64 |
| CHEMBL3238131 | — | — | 1 | 4.52 |
| CHEMBL3238125 | — | — | 1 | 4.39 |
| CHEMBL3238121 | — | — | 1 | 4.25 |
| CHEMBL3238127 | — | — | 1 | 4.19 |
| CHEMBL3238126 | — | — | 1 | - |
| CHEMBL3238124 | — | — | 1 | - |
| CHEMBL3238122 | — | — | 1 | - |
| CHEMBL3238120 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3238134 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3238133 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL204656 | ELVITEGRAVIR | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3238130 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3238128 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL254316 | RALTEGRAVIR | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL3238132 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3238123 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3238129 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3238131 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3238125 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL3238121 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL3238127 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3238126 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL3238124 | — | IC50 | > | 111000.0 | nM | - |
| CHEMBL3238122 | — | IC50 | > | 111000.0 | nM | - |
| CHEMBL3238120 | — | IC50 | > | 333000.0 | nM | - |