Assay Detail
Binding
CHEMBL3241015
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Inhibition of Influenza A virus (A/California/04/2009(H1N1)) wild-type neuraminidase using MU-NANA as substrate after 1 hr
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/California/04/2009(H1N1)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.73 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3238014 | — | — | 1 | 9.06 |
| CHEMBL3238015 | — | — | 1 | 8.76 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.68 |
| CHEMBL3238021 | — | — | 1 | 8.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3238014 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL3238015 | — | IC50 | = | 1.73 | nM | 8.76 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3238021 | — | IC50 | = | 3.7 | nM | 8.43 |