Assay Detail
Binding
CHEMBL3241017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (A/Anhui/1/2005(H5N1)) wild-type neuraminidase using MU-NANA as substrate after 1 hr
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/Anhui/1/2005(H5N1)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.85 | 8.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3238014 | — | — | 1 | 8.88 |
| CHEMBL3238015 | — | — | 1 | 8.44 |
| CHEMBL3238021 | — | — | 1 | 7.48 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3238014 | — | IC50 | = | 1.32 | nM | 8.88 |
| CHEMBL3238015 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3238021 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 250.0 | nM | 6.60 |