Assay Detail
Functional
CHEMBL3241207
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against cell culture derived Hepatitis C virus expressing NS5A-GFP fusion protein infected in human HuH7 cells assessed as infection rate preincubated for 2 hrs followed by viral inoculation measured after 72 hrs by HTS assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-iminobenzimidazoles as potent hepatitis C virus inhibitors with a novel mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 7.03 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3235780 | — | — | 1 | 9.00 |
| CHEMBL3235775 | — | — | 1 | 8.48 |
| CHEMBL3235778 | — | — | 1 | 8.01 |
| CHEMBL3235776 | — | — | 1 | 7.96 |
| CHEMBL3235767 | — | — | 1 | 7.80 |
| CHEMBL3235777 | — | — | 1 | 7.40 |
| CHEMBL3235769 | — | — | 1 | 7.35 |
| CHEMBL1530011 | — | — | 1 | 7.34 |
| CHEMBL3235768 | — | — | 1 | 7.30 |
| CHEMBL3235771 | — | — | 1 | 7.30 |
| CHEMBL2136151 | — | — | 1 | 7.14 |
| CHEMBL3235765 | — | — | 1 | 7.10 |
| CHEMBL3235781 | — | — | 1 | 7.05 |
| CHEMBL3235779 | — | — | 1 | 6.89 |
| CHEMBL3235762 | — | — | 1 | 6.77 |
| CHEMBL3235770 | — | — | 1 | 6.70 |
| CHEMBL3235763 | — | — | 1 | 6.66 |
| CHEMBL3235766 | — | — | 1 | 6.47 |
| CHEMBL3235764 | — | — | 1 | 6.42 |
| CHEMBL3235761 | — | — | 1 | 6.34 |
| CHEMBL3235772 | — | — | 1 | 5.64 |
| CHEMBL1488993 | — | — | 1 | 5.40 |
| CHEMBL3235773 | — | — | 1 | 5.22 |
| CHEMBL3233040 | — | — | 1 | - |
| CHEMBL3235774 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3235780 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3235775 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3235778 | — | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL3235776 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3235767 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3235777 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3235769 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1530011 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3235768 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3235771 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2136151 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3235765 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3235781 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3235779 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3235762 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3235770 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3235763 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3235766 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3235764 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3235761 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3235772 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1488993 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3235773 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3233040 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3235774 | — | EC50 | > | 20000.0 | nM | - |