Assay Detail
Binding
CHEMBL3241282
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Inhibition of vitronectin binding to human alphavbeta3 integrin receptor after 1 hr by competitive solid-phase binding ELISA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pharmacophoric modifications lead to superpotent αvβ3 integrin ligands with suppressed α5β1 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.09 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 9.27 |
| CHEMBL3233260 | — | — | 1 | 9.19 |
| CHEMBL3233259 | — | — | 1 | 9.07 |
| CHEMBL3233263 | — | — | 1 | 8.80 |
| CHEMBL3233262 | — | — | 1 | 7.12 |
| CHEMBL3233258 | — | — | 1 | 6.96 |
| CHEMBL3233261 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL3233260 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL3233259 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL3233263 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3233262 | — | IC50 | = | 75.1 | nM | 7.12 |
| CHEMBL3233258 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3233261 | — | IC50 | = | 638.0 | nM | 6.20 |