Assay Detail
Binding
CHEMBL3241348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method
27
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.38 | 7.52 |
| Inhibition | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.52 |
| CHEMBL3236084 | — | — | 1 | 6.54 |
| CHEMBL3236088 | — | — | 1 | 5.85 |
| CHEMBL3236083 | — | — | 1 | 5.80 |
| CHEMBL3236090 | — | — | 1 | 5.49 |
| CHEMBL3236098 | — | — | 1 | 5.43 |
| CHEMBL3236093 | — | — | 1 | 5.38 |
| CHEMBL3235782 | — | — | 1 | 5.30 |
| CHEMBL3235785 | — | — | 1 | 5.22 |
| CHEMBL3236092 | — | — | 1 | 5.21 |
| CHEMBL1094079 | — | — | 1 | 5.19 |
| CHEMBL3236099 | — | — | 1 | 5.17 |
| CHEMBL3235783 | — | — | 1 | 4.90 |
| CHEMBL3235784 | — | — | 1 | 4.90 |
| CHEMBL3236087 | — | — | 1 | 4.89 |
| CHEMBL1094988 | — | — | 1 | 4.89 |
| CHEMBL278020 | NEOSTIGMINE | 4.0 | 1 | 4.66 |
| CHEMBL3236091 | — | — | 1 | 4.51 |
| CHEMBL3235786 | — | — | 1 | - |
| CHEMBL3236089 | — | — | 1 | - |
| CHEMBL3236086 | — | — | 1 | - |
| CHEMBL3236085 | — | — | 1 | - |
| CHEMBL3236094 | — | — | 1 | - |
| CHEMBL3236095 | — | — | 1 | - |
| CHEMBL3236096 | — | — | 1 | - |
| CHEMBL3236097 | — | — | 1 | - |
| CHEMBL3236082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3236084 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3236088 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL3236083 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL3236090 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL3236098 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL3236093 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL3235782 | — | IC50 | = | 4980.0 | nM | 5.30 |
| CHEMBL3235785 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL3236092 | — | IC50 | = | 6220.0 | nM | 5.21 |
| CHEMBL1094079 | — | IC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL3236099 | — | IC50 | = | 6690.0 | nM | 5.17 |
| CHEMBL3235783 | — | IC50 | = | 12540.0 | nM | 4.90 |
| CHEMBL3235784 | — | IC50 | = | 12610.0 | nM | 4.90 |
| CHEMBL3236087 | — | IC50 | = | 12770.0 | nM | 4.89 |
| CHEMBL1094988 | — | IC50 | = | 12910.0 | nM | 4.89 |
| CHEMBL278020 | NEOSTIGMINE | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3236091 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL3235786 | — | Inhibition | = | 33.6 | % | - |
| CHEMBL3236089 | — | Inhibition | = | 36.4 | % | - |
| CHEMBL3236086 | — | Inhibition | = | 34.2 | % | - |
| CHEMBL3236085 | — | Inhibition | = | 36.5 | % | - |
| CHEMBL3236094 | — | Inhibition | = | 30.3 | % | - |
| CHEMBL3236095 | — | Inhibition | = | 31.2 | % | - |
| CHEMBL3236096 | — | Inhibition | = | 36.6 | % | - |
| CHEMBL3236097 | — | Inhibition | = | 34.1 | % | - |
| CHEMBL3236082 | — | Inhibition | = | 29.2 | % | - |