Assay Detail
Binding
CHEMBL3241548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli by stopped flow CO2 hydration assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.47 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233394 | — | — | 1 | 7.06 |
| CHEMBL3233392 | — | — | 1 | 5.31 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 5.22 |
| CHEMBL3233387 | — | — | 1 | 5.09 |
| CHEMBL3233389 | — | — | 1 | 5.09 |
| CHEMBL3233388 | — | — | 1 | 5.03 |
| CHEMBL3233386 | — | — | 1 | - |
| CHEMBL2016952 | — | — | 1 | - |
| CHEMBL3233390 | — | — | 1 | - |
| CHEMBL3233391 | — | — | 1 | - |
| CHEMBL3233393 | — | — | 1 | - |
| CHEMBL3233395 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233394 | — | Ki | = | 87.3 | nM | 7.06 |
| CHEMBL3233392 | — | Ki | = | 4870.0 | nM | 5.31 |
| CHEMBL310671 | SACCHARIN | Ki | = | 5950.0 | nM | 5.22 |
| CHEMBL3233387 | — | Ki | = | 8058.0 | nM | 5.09 |
| CHEMBL3233389 | — | Ki | = | 8106.0 | nM | 5.09 |
| CHEMBL3233388 | — | Ki | = | 9315.0 | nM | 5.03 |
| CHEMBL3233386 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL2016952 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3233390 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3233391 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3233393 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3233395 | — | Ki | > | 50000.0 | nM | - |