Assay Detail
Binding
CHEMBL3241554
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Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.87 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233394 | — | — | 1 | 8.07 |
| CHEMBL3233392 | — | — | 1 | 7.32 |
| CHEMBL3233395 | — | — | 1 | 7.30 |
| CHEMBL3233389 | — | — | 1 | 7.05 |
| CHEMBL3233386 | — | — | 1 | 7.02 |
| CHEMBL3233393 | — | — | 1 | 7.02 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.99 |
| CHEMBL3233391 | — | — | 1 | 6.47 |
| CHEMBL3233390 | — | — | 1 | 6.35 |
| CHEMBL3233387 | — | — | 1 | 6.33 |
| CHEMBL3233388 | — | — | 1 | 6.32 |
| CHEMBL2016952 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233394 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL3233392 | — | Ki | = | 47.8 | nM | 7.32 |
| CHEMBL3233395 | — | Ki | = | 49.5 | nM | 7.30 |
| CHEMBL3233389 | — | Ki | = | 89.7 | nM | 7.05 |
| CHEMBL3233386 | — | Ki | = | 95.8 | nM | 7.02 |
| CHEMBL3233393 | — | Ki | = | 95.7 | nM | 7.02 |
| CHEMBL310671 | SACCHARIN | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL3233391 | — | Ki | = | 341.0 | nM | 6.47 |
| CHEMBL3233390 | — | Ki | = | 443.0 | nM | 6.35 |
| CHEMBL3233387 | — | Ki | = | 466.0 | nM | 6.33 |
| CHEMBL3233388 | — | Ki | = | 484.0 | nM | 6.32 |
| CHEMBL2016952 | — | Ki | = | 610.0 | nM | 6.21 |