Assay Detail
Binding
CHEMBL3241555
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Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped flow CO2 hydration assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.44 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233394 | — | — | 1 | 8.02 |
| CHEMBL3233389 | — | — | 1 | 7.24 |
| CHEMBL3233392 | — | — | 1 | 7.09 |
| CHEMBL3233388 | — | — | 1 | 7.06 |
| CHEMBL3233393 | — | — | 1 | 6.70 |
| CHEMBL3233395 | — | — | 1 | 6.24 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.20 |
| CHEMBL3233387 | — | — | 1 | 6.18 |
| CHEMBL3233390 | — | — | 1 | 6.13 |
| CHEMBL3233391 | — | — | 1 | 6.06 |
| CHEMBL2016952 | — | — | 1 | 5.56 |
| CHEMBL3233386 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233394 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL3233389 | — | Ki | = | 57.3 | nM | 7.24 |
| CHEMBL3233392 | — | Ki | = | 81.2 | nM | 7.09 |
| CHEMBL3233388 | — | Ki | = | 86.2 | nM | 7.06 |
| CHEMBL3233393 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL3233395 | — | Ki | = | 572.0 | nM | 6.24 |
| CHEMBL310671 | SACCHARIN | Ki | = | 633.0 | nM | 6.20 |
| CHEMBL3233387 | — | Ki | = | 665.0 | nM | 6.18 |
| CHEMBL3233390 | — | Ki | = | 747.0 | nM | 6.13 |
| CHEMBL3233391 | — | Ki | = | 866.0 | nM | 6.06 |
| CHEMBL2016952 | — | Ki | = | 2750.0 | nM | 5.56 |
| CHEMBL3233386 | — | Ki | = | 15600.0 | nM | 4.81 |