Assay Detail
Functional
CHEMBL3241601
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Antiproliferative activity against k-RAS dependent human A549 cells overexpressing WT EGFR after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.63 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237929 | — | — | 1 | 6.04 |
| CHEMBL3237930 | — | — | 1 | 6.00 |
| CHEMBL3237934 | — | — | 1 | 5.99 |
| CHEMBL3237932 | — | — | 1 | 5.95 |
| CHEMBL3237931 | — | — | 1 | 5.92 |
| CHEMBL1229592 | — | — | 1 | 5.68 |
| CHEMBL3237933 | — | — | 1 | 5.58 |
| CHEMBL3237936 | — | — | 1 | 5.55 |
| CHEMBL3237935 | — | — | 1 | 5.28 |
| CHEMBL3237937 | — | — | 1 | 5.08 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237929 | — | IC50 | = | 923.0 | nM | 6.04 |
| CHEMBL3237930 | — | IC50 | = | 1003.0 | nM | 6.00 |
| CHEMBL3237934 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL3237932 | — | IC50 | = | 1119.0 | nM | 5.95 |
| CHEMBL3237931 | — | IC50 | = | 1213.0 | nM | 5.92 |
| CHEMBL1229592 | — | IC50 | = | 2102.0 | nM | 5.68 |
| CHEMBL3237933 | — | IC50 | = | 2622.0 | nM | 5.58 |
| CHEMBL3237936 | — | IC50 | = | 2816.0 | nM | 5.55 |
| CHEMBL3237935 | — | IC50 | = | 5283.0 | nM | 5.28 |
| CHEMBL3237937 | — | IC50 | = | 8251.0 | nM | 5.08 |
| CHEMBL939 | GEFITINIB | IC50 | = | 15580.0 | nM | 4.81 |