Assay Detail
Functional
CHEMBL3241687
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Antimalarial activity against drug-sensitive Plasmodium falciparum NF54
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 6.98 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3234067 | — | — | 1 | 9.18 |
| CHEMBL3234068 | — | — | 1 | 8.46 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.40 |
| CHEMBL3234069 | — | — | 1 | 8.36 |
| CHEMBL3234070 | — | — | 1 | 8.21 |
| CHEMBL3234072 | — | — | 1 | 8.19 |
| CHEMBL3234071 | — | — | 1 | 8.14 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 7.92 |
| CHEMBL3234073 | — | — | 1 | 7.85 |
| CHEMBL3234074 | — | — | 1 | 7.82 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.80 |
| CHEMBL3234041 | — | — | 1 | 7.80 |
| CHEMBL3234042 | — | — | 1 | 7.80 |
| CHEMBL3234094 | — | — | 1 | 7.75 |
| CHEMBL3234075 | — | — | 1 | 7.72 |
| CHEMBL3234043 | — | — | 1 | 7.59 |
| CHEMBL3234076 | — | — | 1 | 7.50 |
| CHEMBL3234044 | — | — | 1 | 7.34 |
| CHEMBL3234077 | — | — | 1 | 7.10 |
| CHEMBL3234093 | — | — | 1 | 7.03 |
| CHEMBL3234045 | — | — | 1 | 7.02 |
| CHEMBL3234078 | — | — | 1 | 7.00 |
| CHEMBL3234079 | — | — | 1 | 6.99 |
| CHEMBL3234080 | — | — | 1 | 6.97 |
| CHEMBL3234081 | — | — | 1 | 6.93 |
| CHEMBL3234047 | — | — | 1 | 6.86 |
| CHEMBL3234046 | — | — | 1 | 6.84 |
| CHEMBL3234083 | — | — | 1 | 6.81 |
| CHEMBL3234085 | — | — | 1 | 6.80 |
| CHEMBL3234084 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3234067 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL3234068 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3234069 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3234070 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3234072 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3234071 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3234073 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3234074 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3234041 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3234042 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3234094 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3234075 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3234043 | — | IC50 | = | 25.9 | nM | 7.59 |
| CHEMBL3234076 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3234044 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3234077 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3234093 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3234045 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3234078 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3234079 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL3234080 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3234081 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3234047 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL3234046 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL3234083 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL3234085 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL3234084 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL3234086 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL3234048 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL3234082 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL3234049 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL3234050 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL3234051 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL3234052 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL3234056 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL3234055 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL3234087 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL3234053 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL3234054 | — | IC50 | = | 603.0 | nM | 6.22 |
| CHEMBL3234089 | — | IC50 | = | 706.0 | nM | 6.15 |
| CHEMBL3234059 | — | IC50 | = | 739.0 | nM | 6.13 |
| CHEMBL3234088 | — | IC50 | = | 763.0 | nM | 6.12 |
| CHEMBL3234098 | — | IC50 | = | 763.0 | nM | 6.12 |
| CHEMBL3234097 | — | IC50 | = | 764.0 | nM | 6.12 |
| CHEMBL3234057 | — | IC50 | = | 964.0 | nM | 6.02 |
| CHEMBL3234058 | — | IC50 | = | 1061.0 | nM | 5.97 |
| CHEMBL3234091 | — | IC50 | = | 1273.0 | nM | 5.89 |