Assay Detail
Functional
CHEMBL3241785
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 by SYBR green I staining-based fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.16 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1209496 | — | — | 1 | 6.72 |
| CHEMBL1209497 | — | — | 1 | 6.66 |
| CHEMBL3236065 | — | — | 1 | 6.58 |
| CHEMBL3236063 | — | — | 1 | 6.30 |
| CHEMBL508668 | — | — | 1 | 6.25 |
| CHEMBL3236060 | — | — | 1 | 6.22 |
| CHEMBL3236059 | — | — | 1 | 6.07 |
| CHEMBL3236067 | — | — | 1 | 5.75 |
| CHEMBL3236068 | — | — | 1 | 5.58 |
| CHEMBL3236066 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1209496 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1209497 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3236065 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3236063 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL508668 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3236060 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3236059 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3236067 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3236068 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3236066 | — | EC50 | = | 3200.0 | nM | 5.50 |