Assay Detail
Binding
CHEMBL3241939
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potentiation of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as increase in glutamate/glycine-induced current response by two-electrode voltage clamp technique relative to control
37
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; Grin1/Grin2c (CHEMBL2096911) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 37 | 4.76 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237286 | — | — | 1 | 5.37 |
| CHEMBL3237289 | — | — | 1 | 5.16 |
| CHEMBL3237250 | — | — | 1 | 5.16 |
| CHEMBL3237287 | — | — | 1 | 5.10 |
| CHEMBL3237291 | — | — | 1 | 5.09 |
| CHEMBL3237285 | — | — | 1 | 5.07 |
| CHEMBL3237253 | — | — | 1 | 5.06 |
| CHEMBL3237257 | — | — | 1 | 5.05 |
| CHEMBL3237292 | — | — | 1 | 5.01 |
| CHEMBL3237254 | — | — | 1 | 4.96 |
| CHEMBL3237256 | — | — | 1 | 4.92 |
| CHEMBL3237294 | — | — | 1 | 4.89 |
| CHEMBL3237293 | — | — | 1 | 4.89 |
| CHEMBL3237284 | — | — | 1 | 4.89 |
| CHEMBL3237301 | — | — | 1 | 4.85 |
| CHEMBL3237275 | — | — | 1 | 4.82 |
| CHEMBL3237260 | — | — | 1 | 4.82 |
| CHEMBL3237281 | — | — | 2 | 4.80 |
| CHEMBL3237268 | — | — | 1 | 4.80 |
| CHEMBL3237252 | — | — | 1 | 4.80 |
| CHEMBL3237249 | — | — | 1 | 4.77 |
| CHEMBL3237288 | — | — | 1 | 4.75 |
| CHEMBL478141 | — | — | 1 | 4.62 |
| CHEMBL3237246 | — | — | 1 | 4.62 |
| CHEMBL3237290 | — | — | 1 | 4.60 |
| CHEMBL3237270 | — | — | 1 | 4.54 |
| CHEMBL3237277 | — | — | 1 | 4.46 |
| CHEMBL3237278 | — | — | 1 | 4.44 |
| CHEMBL3237279 | — | — | 1 | 4.43 |
| CHEMBL3237298 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237286 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3237289 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3237250 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3237287 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3237291 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3237285 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3237253 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3237257 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL3237292 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL3237254 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3237256 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3237284 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3237293 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3237294 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3237301 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3237260 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3237275 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3237252 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3237281 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3237268 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3237249 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3237288 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3237281 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3237246 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL478141 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3237290 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3237270 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3237277 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3237278 | — | EC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3237279 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3237298 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3237295 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3237276 | — | EC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL3237248 | — | EC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL3237300 | — | EC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL3237247 | — | EC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL3237302 | — | EC50 | = | 105000.0 | nM | - |