Assay Detail
Functional
CHEMBL3242011
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Antiplasmodial activity against ring stage synchronized Plasmodium falciparum 3D7 infected in erythrocytes assessed as parasitemia level after 48 hrs by flow cytometry relative to control
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthetic indole and melatonin derivatives exhibit antimalarial activity on the cell cycle of the human malaria parasite Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.74 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082723 | CIPARGAMIN | 2.0 | 1 | 8.00 |
| CHEMBL3233985 | — | — | 1 | 5.53 |
| CHEMBL288084 | — | — | 1 | 4.72 |
| CHEMBL3233984 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082723 | CIPARGAMIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3233985 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL288084 | — | IC50 | = | 19170.0 | nM | 4.72 |
| CHEMBL3233984 | — | IC50 | = | 19100.0 | nM | 4.72 |