Assay Detail
Binding
CHEMBL3242251
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Inhibition of HIV-1 integrase strand transfer activity using 3'-end biotin labelled oligonucleotide/5'-end digoxigenin labelled oligonucleotide as substrate after 1 hr by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.20 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259011 | — | — | 1 | 6.85 |
| CHEMBL3233021 | — | — | 1 | 6.58 |
| CHEMBL3233908 | — | — | 1 | 6.38 |
| CHEMBL3233907 | — | — | 1 | 5.96 |
| CHEMBL3233898 | — | — | 1 | 5.81 |
| CHEMBL3233902 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259011 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3233021 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3233908 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3233907 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL3233898 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL3233902 | — | IC50 | = | 2510.0 | nM | 5.60 |