Assay Detail
Binding
CHEMBL3242429
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Displacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies toward the discovery of selective apelin receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.83 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350781 | — | — | 1 | 5.65 |
| CHEMBL3234454 | — | — | 1 | 4.01 |
| CHEMBL3234446 | — | — | 1 | - |
| CHEMBL3234453 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350781 | — | Ki | = | 2230.0 | nM | 5.65 |
| CHEMBL3234454 | — | Ki | = | 98000.0 | nM | 4.01 |
| CHEMBL3234446 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3234453 | — | Ki | > | 1000000.0 | nM | - |