Assay Detail
Functional
CHEMBL3242464
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 infected in RBC assessed as inhibition of [3H]-hypoxanthine incorporation after 48 hrs by beta-counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Aryl-3H-indol-3-ones: synthesis, electrochemical behaviour and antiplasmodial activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.93 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207675 | SODIUM ARESUNATE | — | 1 | 8.22 |
| CHEMBL3238541 | — | — | 1 | 7.31 |
| CHEMBL3238540 | — | — | 1 | 7.10 |
| CHEMBL3238542 | — | — | 1 | 7.06 |
| CHEMBL3238538 | — | — | 1 | 7.00 |
| CHEMBL3238543 | — | — | 1 | 7.00 |
| CHEMBL3238539 | — | — | 1 | 6.85 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.82 |
| CHEMBL3238537 | — | — | 1 | 6.72 |
| CHEMBL3238536 | — | — | 1 | 6.29 |
| CHEMBL3238535 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207675 | SODIUM ARESUNATE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3238541 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3238540 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3238542 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3238538 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3238543 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3238539 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL3238537 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL3238536 | — | IC50 | = | 514.0 | nM | 6.29 |
| CHEMBL3238535 | — | IC50 | = | 1327.0 | nM | 5.88 |