Assay Detail
Functional
CHEMBL3242949
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Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 72 hrs by CCK8 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.70 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237187 | — | — | 1 | 7.25 |
| CHEMBL3237166 | — | — | 1 | 7.12 |
| CHEMBL3237164 | — | — | 1 | 7.07 |
| CHEMBL3237165 | — | — | 1 | 6.94 |
| CHEMBL3237169 | — | — | 1 | 6.91 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.90 |
| CHEMBL3237188 | — | — | 1 | 6.86 |
| CHEMBL3237181 | — | — | 1 | 6.79 |
| CHEMBL3237168 | — | — | 1 | 6.69 |
| CHEMBL3237184 | — | — | 1 | 6.62 |
| CHEMBL3237185 | — | — | 1 | 6.61 |
| CHEMBL3237172 | — | — | 1 | 6.45 |
| CHEMBL3237174 | — | — | 1 | 6.24 |
| CHEMBL3237176 | — | — | 1 | 6.14 |
| CHEMBL3237167 | — | — | 1 | 5.92 |
| CHEMBL3237180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237187 | — | IC50 | = | 56.4 | nM | 7.25 |
| CHEMBL3237166 | — | IC50 | = | 75.7 | nM | 7.12 |
| CHEMBL3237164 | — | IC50 | = | 84.4 | nM | 7.07 |
| CHEMBL3237165 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL3237169 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL3237188 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL3237181 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL3237168 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL3237184 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3237185 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL3237172 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL3237174 | — | IC50 | = | 571.0 | nM | 6.24 |
| CHEMBL3237176 | — | IC50 | = | 716.0 | nM | 6.14 |
| CHEMBL3237167 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3237180 | — | IC50 | - | — | - |