Assay Detail
Functional
CHEMBL3243053
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Cytotoxicity against human SJSA1 cells assessed as growth inhibition after 16 hrs by EdU incorporation assay in presence of 10% human serum
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SJSA-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.05 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3125527 | — | — | 1 | 8.49 |
| CHEMBL3233140 | — | — | 1 | 7.60 |
| CHEMBL3233141 | — | — | 1 | 7.50 |
| CHEMBL3233126 | — | — | 1 | 7.48 |
| CHEMBL3233137 | — | — | 1 | 7.48 |
| CHEMBL3233123 | — | — | 1 | 7.46 |
| CHEMBL3233125 | — | — | 1 | 7.43 |
| CHEMBL3233130 | — | — | 1 | 7.43 |
| CHEMBL3233122 | — | — | 1 | 7.27 |
| CHEMBL3233127 | — | — | 1 | 7.24 |
| CHEMBL3233138 | — | — | 1 | 7.17 |
| CHEMBL3233124 | — | — | 1 | 6.99 |
| CHEMBL3233139 | — | — | 1 | 6.92 |
| CHEMBL3233136 | — | — | 1 | 6.89 |
| CHEMBL3233129 | — | — | 1 | 6.82 |
| CHEMBL3233134 | — | — | 1 | 6.71 |
| CHEMBL3233131 | — | — | 1 | 6.70 |
| CHEMBL3233133 | — | — | 1 | 6.50 |
| CHEMBL3233132 | — | — | 1 | 6.38 |
| CHEMBL3233121 | — | — | 1 | 6.30 |
| CHEMBL3233135 | — | — | 1 | 6.19 |
| CHEMBL3233128 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3125527 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3233140 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3233141 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3233126 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3233137 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3233123 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3233125 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3233130 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3233122 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3233127 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3233138 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3233124 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL3233139 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3233136 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL3233129 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3233134 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL3233131 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL3233133 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL3233132 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL3233121 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3233135 | — | IC50 | = | 641.0 | nM | 6.19 |
| CHEMBL3233128 | — | IC50 | = | 800.0 | nM | 6.10 |