Assay Detail
Binding
CHEMBL3243169
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CCR2 in human monocytes assessed as reduction of chemotaxis in presence of 0.1 M BSA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.30 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233186 | — | — | 1 | 9.70 |
| CHEMBL3233188 | — | — | 1 | 9.70 |
| CHEMBL1091605 | — | — | 1 | 9.30 |
| CHEMBL3233184 | — | — | 1 | 9.22 |
| CHEMBL3233178 | — | — | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233186 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3233188 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1091605 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3233184 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3233178 | — | IC50 | = | 2.6 | nM | 8.59 |