Assay Detail
Binding
CHEMBL3243657
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Inhibition of electric eel AChE type VI-S using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins prior to substrate challenge for 15 mins by Ellman's method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel structural hybrids of pyrazolobenzothiazines with benzimidazoles as cholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.02 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237466 | — | — | 1 | 7.96 |
| CHEMBL3237473 | — | — | 1 | 7.89 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 7.50 |
| CHEMBL3237457 | — | — | 1 | 7.39 |
| CHEMBL3237472 | — | — | 1 | 7.27 |
| CHEMBL3237467 | — | — | 1 | 6.91 |
| CHEMBL3237458 | — | — | 1 | 6.31 |
| CHEMBL3237455 | — | — | 1 | 6.27 |
| CHEMBL3237462 | — | — | 1 | 6.00 |
| CHEMBL3237454 | — | — | 1 | 5.99 |
| CHEMBL3237453 | — | — | 1 | 5.95 |
| CHEMBL3237459 | — | — | 1 | 5.94 |
| CHEMBL3237460 | — | — | 1 | 5.71 |
| CHEMBL3237456 | — | — | 1 | 5.54 |
| CHEMBL3237464 | — | — | 1 | 5.52 |
| CHEMBL3237468 | — | — | 1 | 5.42 |
| CHEMBL3237471 | — | — | 1 | 5.28 |
| CHEMBL3237463 | — | — | 1 | 5.21 |
| CHEMBL3237461 | — | — | 1 | 5.16 |
| CHEMBL3237465 | — | — | 1 | 5.16 |
| CHEMBL3237470 | — | — | 1 | 5.15 |
| CHEMBL3233057 | — | — | 1 | 5.12 |
| CHEMBL3237469 | — | — | 1 | 5.10 |
| CHEMBL278020 | NEOSTIGMINE | 4.0 | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237466 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3237473 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3237457 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3237472 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3237467 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL3237458 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL3237455 | — | IC50 | = | 541.0 | nM | 6.27 |
| CHEMBL3237462 | — | IC50 | = | 993.0 | nM | 6.00 |
| CHEMBL3237454 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3237453 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL3237459 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL3237460 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL3237456 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL3237464 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL3237468 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL3237471 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL3237463 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL3237461 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL3237465 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3237470 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL3233057 | — | IC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL3237469 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL278020 | NEOSTIGMINE | IC50 | = | 22200.0 | nM | 4.65 |