Assay Detail
Binding
CHEMBL3243854
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Inhibition of Aurora A (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 60 mins
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.33 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237167 | — | — | 1 | 8.30 |
| CHEMBL3237169 | — | — | 1 | 8.11 |
| CHEMBL3237166 | — | — | 1 | 8.10 |
| CHEMBL3237187 | — | — | 1 | 8.00 |
| CHEMBL3237168 | — | — | 1 | 7.96 |
| CHEMBL3237164 | — | — | 1 | 7.92 |
| CHEMBL3237188 | — | — | 1 | 7.89 |
| CHEMBL3237165 | — | — | 1 | 7.80 |
| CHEMBL3237181 | — | — | 1 | 7.66 |
| CHEMBL3237184 | — | — | 1 | 7.66 |
| CHEMBL3237174 | — | — | 1 | 7.60 |
| CHEMBL3237180 | — | — | 1 | 7.50 |
| CHEMBL3237176 | — | — | 1 | 7.47 |
| CHEMBL3237185 | — | — | 1 | 7.47 |
| CHEMBL3237172 | — | — | 1 | 7.34 |
| CHEMBL3237179 | — | — | 1 | 7.14 |
| CHEMBL3237171 | — | — | 1 | 7.01 |
| CHEMBL3237182 | — | — | 1 | 7.00 |
| CHEMBL3237190 | — | — | 1 | 6.95 |
| CHEMBL3237175 | — | — | 1 | 6.95 |
| CHEMBL3237189 | — | — | 1 | 6.93 |
| CHEMBL3237170 | — | — | 1 | 6.90 |
| CHEMBL3237173 | — | — | 1 | 6.87 |
| CHEMBL3237186 | — | — | 1 | 6.83 |
| CHEMBL3237183 | — | — | 1 | 6.70 |
| CHEMBL3237178 | — | — | 1 | 6.64 |
| CHEMBL3237163 | — | — | 1 | 6.26 |
| CHEMBL3237177 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237167 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3237169 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3237166 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3237187 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3237168 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3237164 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3237188 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3237165 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3237181 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3237184 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3237174 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3237180 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3237176 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3237185 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3237172 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3237179 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL3237171 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL3237182 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3237190 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL3237175 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL3237189 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL3237170 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL3237173 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL3237186 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL3237183 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3237178 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL3237163 | — | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL3237177 | — | IC50 | = | 573.0 | nM | 6.24 |