Assay Detail
Binding
CHEMBL3253107
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Inhibition of 5-HT transporter in NMRI albino mouse brain assessed as [3H]5-HT accumulation in hypothalamus after 5 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Hypothalamus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL4642) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Antidepressant agents. 9. 3,3-Diphenylcyclobutylamines, a new class of central stimulants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.61 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 7.16 |
| CHEMBL3251303 | — | — | 1 | 6.05 |
| CHEMBL3251301 | — | — | 1 | 5.55 |
| CHEMBL3251302 | — | — | 1 | 5.52 |
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 5.03 |
| CHEMBL405 | AMPHETAMINE | 4.0 | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3251303 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3251301 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3251302 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL72 | DESIPRAMINE | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL405 | AMPHETAMINE | IC50 | = | 45000.0 | nM | 4.35 |