Assay Detail

CHEMBL3254083

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of Plasmodium berghei dihydrofolate reductase

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Plasmodium berghei
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity.

Elslager EF, Hutt MP, Jacob P, Johnson J, Temporelli B, Werbel LM, Worth DF, Rane L.
J Med Chem (1979) 22 : 1247 -1257
PubMed 117107 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.62	8.62

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL268584	—	—	1	8.62

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL268584	—	IC50	=	2.4	nM	8.62